Indeed, many feel that erythromelalgia is a neurologic disorder. The Merck Manual, 17th ed. However, evidence suggests that it results from abnormalities in the normal narrowing vasoconstriction and widening vasodilation of the diameter caliber of certain blood vessels, leading to abnormalities in blood flow to the extremities. Females are more affected than males. Erythromelalgia may be an isolated, primary condition or occur secondary to various underlying disorders. The use of lidocaine topically such as in a lidocaine patch, and topical preparations designed to block the opening of sodium channels in nerve amitriptyline combined with ketamine for example have been described to be helpful in many patients, either alone or in combination with oral treatments.
In addition, evidence suggests that erythromelalgia may also occur as an adverse effect secondary to the administration of certain drugs e.
Managing Sensory Symptoms of Multiple Sclerosis
Essential thrombocythemia thrombocytosis is considered a myeloproliferative disorder, meaning that it is characterized by abnormalities of certain bone marrow i. Microvascular arteriovenous shunting is a probable pathogenic mechanism in erythromelalgia. In essential thrombocythemia, there is abnormally increased production of platelets thrombocyteswhich are essential in blood clotting. Peripheral neuropathy is a general term used to describe a group of neurological conditions that affect nerves known as peripheral nerves, which extend from the brain or spinal cord central nervous system to muscles, glands, skin, sensory organs, and internal organs. Curr Treat Options Cardiovasc Med.